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Flash Chromatography

Manual Flash System

Economic low-tech method for the synthesis laboratory suited for the separation of compounds up to gram levels no expensive equipment required

Flash

Manual Flash System

MN flash chromatography kits include a glass column, eluent reservoir, silica 60 and accessories. These columns are normally filled to a height of about 15 cm, working pressures are 1.5 to 2 bar.

The most used adsorbent is silica 60 with particle size 40 – 63 μm , however, you may also use range of POLYGOPREP silica phases.

Particle sizes < 25 μm should only be used with very low-viscosity mobile phases, because otherwise flow rates will be very low.

Flash RS Cartridges
ideal for Flash separations from 10 mg up to 160 g

For convenient operation and reliable upscaling the complete program of ready-to-use Flash cartridges for the ISCO®Companion®and other Teledyne IscoCombiFlash®systems, or as stand-alone version for all pump/detector combinations, e.g. from Biotage®, Büchi®,from 4 g to 1600 g adsorbent from one of the leading companies in silica and TLC business

Increases analytical safety high pressure stability of 15 bar/220 psi (12 bar for cartridges > 200 g), excellent separation efficiency, good reproducibility

Loadability

Due to the narrow particle size distribution, the excellent packing quality and the optimised stationary phases (acid washed silica, reduced particulate matter) cartridges can realize highest loadability at best possible separation efficiency. Additionally, the large range of different cartridge lengths and diameters eases to find the optimum in loadability for a given sample amount.

Back pressure/pressure stability

The back pressure always depends on flow rate and viscosity of the eluent mixture, column length, diameter and particle size. The new ultra performance CHROMABOND®Flash RS cartridges up to 200 g silica are stable up to 15 bar (220 psi, > 200 g: 12 bar)

We recommend a pressure guard, because short time pressure peaks (viscosity of eluent or change in gradient) can exceed the pressure limit.

SiOH Cartridge Average loadability per cartridge [g]
  Difficult separation Easy separation
RS 4 0.04 0.04
RS 15 0.15 1.5
RS 25 0.25 2.5
RS 40 0.4 4
RS 80 0.8 8
RS 120 1.2 12
RS 200 2 20
RS 330 3.3 33
RS 800 8 80
RS 1600 16 160

Flash adsorbents

All Flash columns and cartridges from MN are available with whole range of CHROMABOND® phases (more than 40, e. g. C18, C8, OH, Alox etc.)

Flash Packings

Flash Packings

Additionally you can choose from range of POLYGOPREP silica packings in particle sizes from 20 to 130 μm and pore sizes from 60 to 4000 Å.

The most used adsorbent is silica 60 with particle size 40 – 63 μm , however, you may also use range of POLYGOPREP silica phases.

For high performance Flash separations you can order columns packed with spherical NUCLEODUR®featuring very high separation efficiency and extremely increased column lifetime (particle size > 20 μm)

For more detail, check Bulk Packing Section

Flash Safety System

Features:

Flash Holder40

Flash Holder40

  • Maximum safety during use under pressure
  • Increased column life time
  • High separation efficiency
  • Excellent reproducibility
  • High loadability
  • Easy and flexible installation, even with different instruments / hardware

The CHROMABOND®Flash Safety System

  • Can be used as stand-alone system for any pump / detector / fraction collector combination with ¼"-28 fittings
  • CHROMABOND® safety holder, available in 5 different sizes (90, 180, 240, 360, 750/1000 ml)
  • Holder can be equipped with either luer lock inlet, ¼"-28 threads or Swagelok ®connection
  • Cartridges with luer lock exit for a safe and pressure stable tube connection
  • Maximum safety up to 9 bar
FlashHolder65

FlashHolder65

Flash Injection System

Alternative injection systems and methods (in stand-alone mode)

Liquid injection systems: the sample is applied to the flash column e. g. via syringe and 3-way valve or with a VICI®medium pressure valve with sample loop (see figures below)

Solid injection systems: the sample is adsorbed to a suitable adsorbent (e. g. CHROMABOND®XTR), and the loaded adsorbent is filled into a solid injection cartridge fitted with the corresponding adaptor (right figures below)

The solid injection cartridges

  • Can be connected directly to the upper luer lock of the cartridges for a pressure tight connection
  • Are available in 5 different dimensions, because different sample amounts always require adequate solutions
  • Can be filled easily and are reusable
Flash Liquid injection

Flash Liquid injection

Flash Solid injection on RS

Flash Solid injection on RS

Flash Solid injection plus RS

Flash Solid injection plus RS

Flash Solid injection cartridges

Flash Solid injection cartridges

 VICI®medium pressure valve

VICI®medium pressure valve

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