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Solid Phase Extraction

CleanScreen

XCEL

XCEL

The Clean Screen® Xcel solid phase extraction columns are a line of sample prep phases designed to reduce the number of steps in the extraction, and therefore the amount of time and solvent necessary to complete the sample cleanup. Further advantages include reduced sample size and improved cleanliness and recovery. The Xcel I column will extract a wide array of basic drugs including benzodiazepines and opiates. The Xcel II column is designed solely for the extraction of the THC metabolite. See cleanscreenxcel.com for more info.

DAU

DAU

Clean Screen® DAU is the flagship product of the forensic solid phase extraction column line. The first product of its kind in the industry, it is a mixed-mode column exhibiting both hydrophobic and cation exchange characteristics. Over 20 years of experience has shown this column to be effective on hundreds of drugs in both the acid-neutral and basic drug categories.

FASt

fast

The FASt® column is a novel approach to improved sample preparation for LC/MS analysis. The column employs a one step process to prepare urine samples for analysis of multiple drugs and metabolites. By quickly and efficiently reducing the amount of unwanted matrix (through sorbent adsorption) and particulates (filtering through special frits) in the final sample, the analysis can proceed with less chance of matrix suppression and LC column clogging.

THC

THC

Clean Screen® THC is a mixed-mode column, consisting of hydrophobic and anion exchange functionalities. It was the 2nd product in the flagship line and has performed consistently over the last 20 years. UCT's method allows for the extraction of both the parent drug and its metabolites.

GHB

GHB

Clean Screen® GHB is a patented mixed-mode column designed for the filtration extraction of ethylene glycol, butan diol, gamma hydroxy butyrate and butyrolactone.

RSV

RSV

Reduced Solvent Volume is a small particle, small bed SPE column designed for reduced solvent usage and more economical extractions of drugs of abuse and clinical compounds.

BNZ

BNZ

Clean Screen® BNZ is specific for the extraction of 7-Amino Clonazepam.

ETG

ETG

Clean Screen® ETG is a proprietary carbon blend column designed for the extraction of ethyl-glucuronide from urine.

Clean-UP

Anion Exchange

Anion Exchange

Clean-Up® Anion Exchange: Compounds are retained on the sorbent through ionic bonds. Therefore, it is essential that the sorbent and the analyte to be extracted are charged. Generally, the number of molecules with charged cationic groups increases at pH values below the molecules pKa value. The number of molecules with charged anionic groups decreases at pH values below the molecule’s pKa value. To ensure 99% or more ionization, the pH should be at least two pH units below the pKa of the cation and two pH units above the pKa of the anion. Elution occurs by using a solvent to raise the pH above the pKa of the cationic group or to lower the pH below the pKa of the anion to disrupt retention. At this point, the sorbent or compound will be neutralized.

Carbon

Carbon

Clean-Up® Carbon: Carbon supports have been used to isolate extremely polar organic compounds. They work by an adsorption mechanism with a high surface area and ion exchange.

Cation Exchange

Cation Exchange

Clean-Up® Cation Exchange: These sorbents are composed of a silica backbone bonded with a carbon chain terminated by a negatively charged functional group. UCT cation exchange sorbents provide unmatched activity for amines, alcohols and other nucleophiles. Our extensive product line allows the analyst to choose from a wide range of cartridge sizes and chemistries each tailored to the specific requirements of the extraction.

Copolymeric

Copolymeric

Clean-Up® Copolymeric: This sorbent is composed of a silica backbone with two types of functional chains attached - an ion exchanger or polar chain and a hydrophobic carbon chain. Our copolymeric phases are produced in a way to allow for equal parts of each functional group to attach to the silica backbone. This copolymerization technique yields reproducible bonded phases and unique copolymeric chemistries which allow the controlled use of mixed mode separation mechanisms. This type of dual chemistry is beneficial especially when one is looking for both a neutral & charged compound. This is common when a neutral parent drug metabolizes & becomes a charged compound.

Covalent

Covalent

Clean-Up® Covalent: Covalent sorbent has aldehyde functional groups that are bound to the silica backbone by a hydrocarbon chain. The aldehyde group will react selectively with compounds containing a primary amine. A formal bond is created between the stationary support and the primary amine containing material. The primary amine in the sample performs a nucleophilic attack on the aldehyde functional group attached to the support. This results in a Schiff base, with the amine immobilized on the stationary support. This chemistry can be utilized to bind proteins, such as antibodies, to the support, allowing highly specific extractions.

Hydrophilic

Hydrophilic

Clean-Up® Hydrophilic: This sorbent is composed of a silica backbone bonded with carbon chains containing polar functional groups. Groups which will possess such polarity include amines, hydroxyls and carbonyls. Compounds are retained on hydrophilic sorbents through polar interactions including hydrogen bonding, pi-pi or dipole-dipole interaction. These types of interactions occur when a distribution of electrons between individual atoms in functional groups is unequal, causing negative and positive polarity. Compounds typically extracted on a hydrophilic column include analytes which have polar groups, including amines, hydroxyls and carbonyls. Elution is performed by strong polar solvents.

Hydrophobic

Hydrophobic

Clean-Up® Hydrophobic: This sorbent is composed of a silica backbone bonded with hydrocarbon chains. It is used to extract compounds which exhibit non-polar or neutral characteristics out of complex matrices. The C18 phase is the most widely used for non-polar interactions because of its nonselective nature; C18 will extract a large number of compounds with differing chemical properties. To enhance selectivity, UCT offers a wide range of hydrophobic sorbents, from C2 to C20. Multiple chain configurations are available for some sorbents. Endcapped or unendcapped sorbents are available for all chain length.

Styre Screen®

Polymeric PS-DVB Support Columns

Polymeric PS-DVB Support Columns

Advantages of Styre Screen®: Styrene - divinylbenzene copolymeric support material. Functionalized with the same types of phases as our silica supports, including reverse phase, ion-exchange and copolymeric such as DAU and THC. The polymeric support material has high analyte capacity which allows for a reduction in sorbent mass. This translates to faster flow rates and less solvent usage. The support material is pH stable across the entire range from 1 to 14.

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